In light of the study showing that bacteria with a particular form of the protein DnaK can interfere with a cell’s response to DNA damage and the ability to repair such damage, I have been thinking about what kinds of cancers may have a bacterial cause or contribution. The one that the researchers studied to … Read more
In a study of infection by bacteria of the mycoplasma family, researchers at the University of Maryland School of Medicine have discovered that the bacterial protein DnaK triggers a cascade of events that can cause infected cells and nearby uninfected cells to become cancerous. DnaK is a prokaryotic stress-induced protein (Figure 1) that is a … Read more
Changes in how the brain processes memories of pleasurable or rewarding experiences contribute to addiction and depression. A study in mice by LeGates and colleagues provides clues to how the brain processes and remembers rewards, which is key to understanding and treating these mental health disorders. They used light-activated proteins (optogenetics) to alter the strength … Read more
A team of researchers, led by Ronna Hertzano from the University of Maryland School of Medicine (USA) and Michael Bowl from the MRC Harwell Institute (United Kingdom), has identified the gene Ikzf2 as a key regulator critical for the functional maturation of cochlear outer hair cells. The cochlea is part of the inner ear (Figure 1). … Read more
One of the mysteries in scholarly publishing is the peer-review process. I created this short video to help scientists understand the process editors use in selecting reviewers. I describe it as a game of dodge ball. The editor typically has a large pool of potential reviewers who have the right expertise and scientific background, but … Read more