A type of immunotherapy uses antibodies that activate the TNF receptor family member CD40 on immune cells. CD40 is present on antigen-presenting cells (APCs) of the immune system and is activated by surface-bound proteins called CD40L. Activation of CD40 on APCs stimulates these cells to take up and display antigens to T and B cells, … Read more
Calorie restriction and intermittent fasting are both associated with improved health and longevity in many animals. Studies with monkeys and humans are consistent with health benefits of both calorie restriction and intermittent fasting, but the studies are difficult to compare due to differences in the diet and feeding patterns in the monkey studies and the … Read more
Peer review of manuscripts and grants is part of the scientific endeavor and is an important responsibility of research scientists. However, how to do this critical task is rarely taught. Instead, many junior or early career scientists are handed a manuscript or invited to serve as a reviewer without much guidance. Like editors, reviewers serve … Read more