Crowther and colleagues screened clones of T cells isolated from a healthy donor and identified a clone (MC.7.G5) that recognized and killed many different types of cancer cells, including cells from solid tumors. When mixed with lung, melanoma, leukemia, breast, colon, prostate, bone, or ovarian cancer cell lines, MC.7.G5 released tumor necrosis factor (TNF) and … Read more
As cancer therapies increasingly include using the patient’s own immune cells to fight the cancer, a new product has emerged on the market. Cell Vault is a new company that will send anyone a blood collection kit, draw the blood either at home or in an office, and then store the processed sample frozen in … Read more
T cells of the adaptive immune system are not the only cytotoxic cells in the immune system. Natural killer cells (NK cells) are a cytotoxic white blood cell (lymphocyte) of the innate immune system. Clinical trials with NK cells use these as cell-based biologic therapies: The NK cells are the therapy. New research suggests that … Read more
There are now many types of anti-cancer drugs that target the immune system, including those that override the immune system’s natural regulatory processes. These processes function as the brakes on the immune system. The FDA-approved immune checkpoint inhibitors are Keytruda (pembrolizumab), Opdivo (nivolumab), Tecentriq (atezolizumab), and Yervoy (ipilimumab). Several investigational drugs [MK-4166, GWN323, MS-986156, INCAGN01876, … Read more