Single-Cell Proteomics Shines Light on the Complexity of Immune Cells in Solid Tumors

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A Proteomic Approach to the Tumor Microenvironment An outstanding issue in treating solid cancers is understanding the complexity of this pathological tissue. Solid tumors are comprised not only of the cancer cells, but they also contain immune cells, cells that form blood vessels and lymphatic vessels, fibroblasts, and the stem cells that form the fibroblasts … Read more

A Cryobank for T Cells

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As cancer therapies increasingly include using the patient’s own immune cells to fight the cancer, a new product has emerged on the market. Cell Vault is a new company that will send anyone a blood collection kit, draw the blood either at home or in an office, and then store the processed sample frozen in … Read more

Mast Cells Contribute to Osteoarthritis

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Osteoarthritis is the form of arthritis that many people develop as they age. It is associated with breakdown of the cartilage in joints, causing pain and difficulty moving the affected joint. In contrast to rheumatoid arthritis, which is an autoimmune disease, osteoarthritis is thought to arise from mechanical wear and tear of the joint or … Read more

Engineering the Immune System to Treat Diabetes

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Some diseases arise because the immune system reacts with normal, healthy cells in the body. In other diseases, lack of an effective immune response contributes to the disease. Cancer cells escape attack by the immune system, in part, by producing a lot of the protein PD-L1 (Gough, 24 May 2017). PD-L1 binds and activates the … Read more