The diagram shows molecular pathways by which resveratrol or pterostilbene can promote healthy cellular metabolism (left) or promote cell death (right). The cells that respond positively increase synthesis of NAD+ through the NAD+ salvage pathway by increasing the amount of the enzyme NAMPT. These cells would have a relatively low metabolism and abundant ATP. In contrast, highly active cells with low ATP may generate ATP with the induced enzyme NAMPT, consequently, cellular NAD+ would decrease and overall cellular metabolism would be compromised resulting in cell death. The key to this switch is the ability of NAMPT to catalyze both the forward reaction, promoting NAD+ regeneration, and the reverse, promoting ATP production at the expense of the NAD+ salvage pathway. Credit: Cell diagrams from BioRender, image compiled by Nancy R. Gough, BioSerendipity, LLC.
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N. R. Gough, Anti-Aging Supplements: The Basis for Basis. BioSerendipity (11 June 2018) https://www.bioserendipity.com/anti-aging-supplements-the-basis-for-basishttps://www.bioserendipity.com/anti-aging-supplements-the-basis-for-basis
N. R. Gough, Anti-Aging Supplements II: NAD+ as the Key to Healthy Aging. BioSerendipity (13 June 2018) https://www.bioserendipity.com/anti-aging-supplements-ii/
N. R. Gough, Anti-Aging Supplements III: Berries and Wine for Healthy Aging. BioSerendipity (20 June 2018) https://www.bioserendipity.com/anti-aging-iii/