Cardiovascular Physiology & Disease

Normal and pathophysiology related to the heart and vascular system

Proteomic Analysis Leads to Insights into Heart Failure

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dilated_cardiomyopathy

Although mass spectrometry-based proteomic analysis is particularly useful for performing global proteomic analysis, this technique can also be used in a more targeted manner. For example, mass spectrometry-based proteomic analysis can be combined with immunoprecipitation to reveal the proteins that interact with the immunoprecipitated protein. Quick and colleagues (1) used coimmunoprecipitation followed by mass spectrometric … Read more

The Power of Proteomics in Vascular Disease

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Carotid_artery_stenosis

This commentary on the power of proteomics highlights research showing how proteomics can advance the diagnosis of atherosclerosis, a type of vascular disease. Langley and colleagues use mass spectrometric analysis to define a 4-protein signature that predicts patients with atherosclerosis who are at risk for a vascular event, such as stroke or heart attack.This study … Read more