Computational analysis of cellular and organismal physiology
A Proteomic Approach to the Tumor Microenvironment An outstanding issue in treating solid cancers is understanding the complexity of this pathological tissue. Solid tumors are comprised not only of the cancer cells, but they also contain immune cells, cells that form blood vessels and lymphatic vessels, fibroblasts, and the stem cells that form the fibroblasts … Read more
Defining >56,000 Human Protein Interactions through Mass Spectrometry Huttlin and colleagues applied mass spectrometric analysis to affinity purified protein complexes to help build a partial reference map of the human protein interaction space (1). The cDNA encoding the target proteins also engineered to have affinity tags (hemagglutinin and FLAG) were introduced into an easily infected … Read more
This commentary on the power of proteomics highlights research showing how proteomics can advance the diagnosis of atherosclerosis, a type of vascular disease. Langley and colleagues use mass spectrometric analysis to define a 4-protein signature that predicts patients with atherosclerosis who are at risk for a vascular event, such as stroke or heart attack.This study … Read more
How will we benefit from being able to accurately predict the peptide antigens that the immune system can recognize? Vaccine development would be a major beneficiary of such knowledge (Figure 1). We could produce more effective and safer vaccines. We could develop vaccines for pathogens for which no vaccine is currently available. We could ensure … Read more