Pharmacology & Drug Discovery

Drug discovery and molecular mechanisms of drug action

Fighting Cancer with the Immune System: Lessons from CAR T Cell Therapy

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CAR-T-cell-killing-cancer-cell-illustration

The Promise of CAR T Cell Therapy Many strategies that train the immune system to recognize and attack cancer are in development or undergoing clinical trials (1). However, these strategies have the potential to cause life-threatening consequences, as evidenced by the latest report of the death of another patient receiving CAR T cell therapy (2). CAR … Read more

Can Denosumab Prevent Breast Cancer?

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Structure_model_denosumab_OPG_RANKL

From Osteoporosis to Breast Cancer Denosumab, a biologic agent, and bisphosphonates, which are small molecule drugs, reduce fractures that are complications of osteoporosis, including those caused by breast cancer hormone therapies that block estrogen signaling, menopause, or surgically-induced menopause (oophorectomy with or without hysterectomy). Both denosumab and bisphosphonates also reduce the risk of bone metastasis … Read more