Regulation and function of and signaling by GPCRs and their downstream effectors
Pancreatic cancer is one of the deadliest forms of cancer with most patients surviving much less than one year from diagnosis. This was certainly the experience that my family had—diagnosis was made at the end of January and the patient died in April. For patients with metastatic disease, combination therapy with conventional chemotherapeutic agents, which … Read more
Researchers commonly refer to the molecular and biochemical events that occur in response to extracellular signals as pathways. There is a tendency to lump a related set of pathways into a general overarching pathway. For example, researchers may refer to the TGF-β pathway or the Wnt pathway. These are no more individual pathways than the … Read more
Overcoming side effects and toxicity of currently FDA-approved is possible. Sometimes combining multiple drugs with different mechanisms of action lets doctors use less of each drug to achieve the desired effect and limit or avoid off-target or dose-limiting effects. This is a common strategy used for anesthesia. Doctors give a “cocktail” of drugs with different … Read more