A Closer Look: 10 March 2019
A list of articles classified by Nancy R. Gough as good, valuable contributions or not so valuable contributions to the scientific literature.
Proteomics
Insights from large- and mid-scale analysis of proteins
The mTOR-Dependent Translatome in Growing Nerves and Injured Axons
Neurons have a distinct shape. The long processes for sending a signal (the axon) and for receiving signals (dendrites) are often far away from the cell body (soma) containing the nucleus. Thus, neurons have sophisticated systems for transporting messenger RNAs (mRNAs) and proteins involved in protein synthesis to these cellular processes for locally regulated protein … Read more
The Central Role of Mitochondria in Red Blood Cells
Ferrochelatase in heme biosynthesis Ferrochelatase (FECH) is an enzyme found in mitochondria that adds iron ions (Fe2+) into protoporphyrin to produce heme (Figure 1). This biochemical reaction is critical for cell health. The process is tightly controlled so that cells produce the amount of heme needed and do not accumulate too much of the heme … Read more
Drug Repurposing: Preventing Blindness with an Antifungal
Benefits of Off-Target Effects There are many FDA-approved medicines. Most have some “off-target” effects, meaning effects that are not those intended for the drug. Sometimes these off-target effects limit the dose of a drug that can be used to treat the intended disease or symptom. Sometimes these off-target effects are unwanted side effects that the … Read more
The Power of Proteomics in Medicine
Although genomic (DNA) and transcriptomic (messenger RNA) data are easier to collect and analyze, these are only two of the relevant types of “omic” data that are important for understanding disease and the response to treatments. Proteomic, metabolomic, and lipidomic data are also contain information that can be used diagnostically, prognostically, in developing treatment … Read more