Type I and type III interferons are critical proteins for responding to viruses. Aberrant interferon signaling may contribute to severe COVID-19. The structure on the left is a type I interferon (PDB: 1rh2) and the structure on the right is a type III interferon (PDB:3OG6). The SARS-CoV-2 virus is shown in the middle. [Credit: Nancy R. Gough, BioSerendipity, LLC]
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