Ketamine was the first compound identified with fast-acting antidepressant action. The other molecules are under investigation for their ability to produce fast-acting antidepressant effects or as precursors of compounds that have this antidepressant action. The chemical structures of ketamine, 7-chlorokynurenic acid, 4-chlorokynurenine, (2R, 6R)-hydroxynorketamine, and MRK-016 (a GABA-NAM) are shown. Structures are from PubChem. Compilation by Nancy R. Gough, BioSerendipity.
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N. R. Gough, Discovering fast-acting treatments for depression. BioSerendipity (11 January 2019) https://www.bioserendipity.com/discovering-fast-acting-treatments-for-depression/.