A diagram showing the inhibitory effect of GDF15 released by the heart and the stimulatory effect of GH released by the brain on the liver-mediated secretion of IGF1. From Wang et al., EMBO Mol. Med. 9, 1150-1164 (2017).
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N. R. Gough, GDF15: Heart Hormone, Appetite Suppressant, Marker of Neurodegenerative Disease. BioSerendipity (19 September 2017) https://www.bioserendipity.com/2017/09/19/gdf15-heart-hormone-appetite-suppressant-marker-of-neurodegenerative-disease/