Sivakumar et al., Organotypic tumor slice cultures provide a versatile platform for immuno-oncology and drug discovery. Journal of OncoImmunology (2019).
Sun et al. Nuclear glycogenolysis modulates histone acetylation in human non-small cell lung cancers. Cell Metabolism (2019).
Wu et al., The Drosophila Hedgehog receptor component Interference hedgehog (Ihog) mediates cell-cell interactions through trans-homophilic binding. Journal of Biological Chemistry (2019).
Rao and Mishra, Targeting transforming growth factor beta signaling in liver cancer. Hepatology (2019).
An and Brognard, Orange in the new black: Kinases are the new master regulators of tumor suppression. IUBMB Life (2019).
Ruiz et al., Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. Nature Communications (2019).
Keskin et al., Regulatory network of the scoliosis-associated genes establishes rostrocaudal patterning of somites in zebrafish. iScience (2019).
Bowling et al., Altered steady state and activity-dependent de novo protein expression in fragile X syndrome. Nature Communications (2019).
Zhu et al., Predicting patient response to the antiarrythimic mexiletine based on genetic variation: Personalized medicine for Long QT Syndrome. Circulation Research (2018).
Torres-Ayuso and Brognard, Shipping out MEK inhibitor resistance with SHP2 inhibitors. Cancer Discovery (2018).
Crinier et al. High-dimensional single-cell analysis identifies organ-specific signatures and conserved NK cell subsets in humans and mice. Immunity (2018).
Kawata et al., Trans-omic analysis reveals selective responses to induced and basal insulin across signaling, transcriptional, and metabolic networks. iScience (2018).
Duke-Cohan et al., Regulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity. Science Signaling (2018).
Katsu et al., Evolution of human, chick, alligator, frog, and zebrafish mineralocorticoid receptors: Allosteric influence on steroid specificity. Science Signaling(2018).
Karamitri et al., Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling. Science Signaling (2018).
Asli et al., “Disruptor” residues in the regulator of G protein signaling (RGS) R12 subfamily attenuate the inactivation of Gα subunits. Science Signaling (2018).
Papasergi-Scott et al., Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange. Science Signaling (2018).
Rollings et al., Interleukin-2 shapes the cytotoxic T cell proteome and immune environment-sensing programs. Science Signaling (2018).
Gonnard et al., A hierarchy of affinities between cytokine receptors and the common gamma chain leads to pathway cross-talk. Science Signaling (2018).
Tu et al., An evolutionarily conserved gene family encodes proton-selective ion channels. Science (2018).
Hackley et al., cAMPr: A single-wavelength fluorescent sensor for cyclic AMP. Science Signaling (2018).
Al-Haj and Khabar, The intracellular pyrimidine 5′-nucleotidase NT5C3A is a negative epigenetic factor in interferon and cytokine signaling. Science Signaling (2018).
Lyons et al., Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis. Science Signaling (2018).
Lauder et al., Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Science Signaling (2017).