Structures of TIMP2 bound to MMP14 (also known as MT1-MMP), TIMP2 bound to MMP2, and the active site of MMP2. The left structure shows MMP14 (blue) bound to TIMP2 (red) from PDB 1BQQ; the middle structure is of the active site of MMP2 from PDB 1QIB, and the right structure shows TIMP2 (yellow) bound to proMMP2 (blue) from PDB 1GXD. Activation of these enzymes may contribute to cancer metastasis.
Find out more: N. R. Gough, Secreted Kinases May Promote Malignancy. BioSerendipity (2 April 2018) https://www.bioserendipity.com/secreted-kinases-may-promote-malignancy