Mast Cells Contribute to Osteoarthritis

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Osteoarthritis is the form of arthritis that many people develop as they age. It is associated with breakdown of the cartilage in joints, causing pain and difficulty moving the affected joint. In contrast to rheumatoid arthritis, which is an autoimmune disease, osteoarthritis is thought to arise from mechanical wear and tear of the joint or … Read more

Optimizing Anti-Tumor Therapies with Engineered Antibodies

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A type of immunotherapy uses antibodies that activate the TNF receptor family member CD40 on immune cells. CD40 is present on antigen-presenting cells (APCs) of the immune system and is activated by surface-bound proteins called CD40L. Activation of CD40 on APCs stimulates these cells to take up and display antigens to T and B cells, … Read more

New Hope for Lyme Disease Prevention

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Lyme disease is caused by bacteria (Borrelia burgdorferi, Borrelia afzelii, and Borrelia garinii) that are delivered by a bite from an infected tick (Figure 1). The Centers for Disease Control (1) recommend a preventative (prophylactic) single dose of the antibiotic doxycycline for adults bitten by a mosquito with a high probability of carrying the Lyme-causing … Read more