Mast Cells Contribute to Osteoarthritis

mast_cells

Osteoarthritis is the form of arthritis that many people develop as they age. It is associated with breakdown of the cartilage in joints, causing pain and difficulty moving the affected joint. In contrast to rheumatoid arthritis, which is an autoimmune disease, osteoarthritis is thought to arise from mechanical wear and tear of the joint or … Read more

Immunomodulators for Arthritis: Small-Molecule Disease-Modifying Agents

rheumatoid_arthritis

Unlike osteoarthritis, rheumatoid arthritis is an autoimmune disease (1). The body’s own immune system attacks the joints, causing swelling, pain, heat, redness, immobility, and tissue damage that can cause deformation (Figure 1). Because rheumatoid arthritis is an autoimmune disease, some types of immunomodulatory agents are specifically useful for treating this condition. Although both types of arthritis … Read more

Stem Cell Injections for Osteoarthritic Knees

Some friends recently asked me about getting stem cell injections for painful knees with osteoarthritis (Figure 1). Should they push their doctors for this treatment? Were they, and consequently their stem cells, going to be too old if they waited? I started my investigation at PubMed, searching for “stem cells” and “osteoarthritis,” which produced 1249 … Read more

Can you be vaccinated against yourself?

Injection

What is a vaccine? A vaccine may be described as medicine that stimulates an immune response with a “memory.” Many people also consider a vaccine to be a medicine that prevents a disease caused by a pathogen. Indeed, the first vaccines were ones that prevented infectious diseases, such as polio and measles. Some vaccines have … Read more