Therapeutic Applications for Inhibitors and Activators of RANKL/RANK Signaling
Target tissue type, as well as a patient’s gender, nutritional, and reproductive status, must be considered to manipulate signaling through the RANKL/RANK pathway for therapeutic benefit. In some contexts, activating this pathway can be beneficial and in others inhibiting this pathway is beneficial. RANKL is the ligand, RANK [receptor activator of nuclear factor kappa-B (NF-κB)] … Read more