A Closer Look: 10 March 2019
A list of articles classified by Nancy R. Gough as good, valuable contributions or not so valuable contributions to the scientific literature.
epigenetics
Anti-Aging Supplements III: Berries and Wine for Healthy Aging
Some anti-aging supplements include compounds, like nicotinamide riboside, that increase nicotinamide adenine dinucleotide (NAD: oxidized NAD+ and reduced NADH) and stilbenoid compounds, like resveratrol or pterostilbene, that are anti-oxidants and regulators of protein function. The findings that resveratrol inhibited human platelet aggregation and prevented cancer cell proliferation in culture and cancer in mice created excitement … Read more
Anti-Aging Supplements II: NAD+ as the Key to Healthy Aging
Cellular and whole-body metabolism changes with age. An emerging idea is that preventing these metabolic changes may reduce negative effects of aging or at least delay them. Indeed, this idea is popular enough that companies are developing and selling dietary supplements intended to boost “healthy” metabolism. Many are intended to boost the amount of a … Read more
Understanding Immune Checkpoint Pathways to Improve Patient Response
Better understanding of the molecular mechanisms that control the adaptive immune system will lead to better immunotherapies for cancer patients or patients with other diseases related to inappropriate immune responses. Two of the processes that inhibit T cell function are called immune checkpoint pathways. New research reveals that these pathways involve many cells of the … Read more