Intratumor Immunotherapy Kills Injected and Distant Tumors

metastatic_cancer

Cancerous tumors must evade immune destruction to survive. They can achieve this by preventing the immune cells from gaining access to the tumor (“immune cold”) or by tipping the balance of immunoactivating and immunosuppressing signals toward immunosuppression. Immunosuppression means that, even if the immune cells penetrate the tumor, they cannot kill the cancer. The cytotoxicity … Read more

Making Immune “Cold” Tumors Hot

Making_Cold_Tumor_Hot

A main goal of current research and clinical trials is to expand the number of patients that benefit from immune checkpoint inhibitors. Thus, it is perhaps not surprising that combination therapies are the future for these immunotherapies in treating cancer. There are many clinical trials that combine an immunotherapy with conventional chemotherapy (drugs that kill … Read more