Src

Secreted Kinases May Promote Malignancy

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protein_secretion

Protein kinases are enzymes that add phosphate groups onto specific amino acids on proteins. Most of these enzymes are active within cells. Kinases are often encoded by oncogenes, and aberrant activity of these regulatory enzymes is frequently associated with cancer. Data are emerging that kinases can also be released from cells. These secreted kinases can … Read more

SRC on the Outside

by
MMP2_activation

Secreted proteins or the parts of transmembrane proteins that are extracellular can be phosphorylated. DeRita and colleagues reported that the cytosolic tyrosine kinase c-SRC was one of several kinases released from prostate cancer cells in exosomes. Sánchez-Pozo and colleagues identified a cancer-relevant function for extracellular c-SRC: c-SRC functioned outside of cultured cells to regulate the … Read more