Two Pathways to Viral Recognition

Structure of MHC class I displaying a SARS-CoV-2 peptide to a T cell receptor

T cells are a major component of the adaptive immune system. The video shows the intracellular events that let T cells learn about and recognize virus-infected cells. Infected cells can use the major histocompatibility complex (MHC) I or MHC II pathway to signal to T cells that they are infected. Both pathways rely on the … Read more

Understanding Immune Checkpoint Pathways to Improve Patient Response

Cells_of_the_immune_system

Better understanding of the molecular mechanisms that control the adaptive immune system will lead to better immunotherapies for cancer patients or patients with other diseases related to inappropriate immune responses. Two of the processes that inhibit T cell function are called immune checkpoint pathways. New research reveals that these pathways involve many cells of the … Read more